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Notification report


Full notification file


General information

Notification Number
B/ES/18/10

Member State to which the notification was sent
Spain

Date of acknowledgement from the Member State Competent Authority
09/05/2018

Title of the Project
Phase I trial of DNX-2440 oncolytic adenovirus in patients with recurrent Glioblastoma

Proposed period of release:
01/09/2018 to 01/09/2020

Name of the Institute(s) or Company(ies)
ClĂ­nica Universidad de Navarra, ;


3. Is the same GMO release planned elsewhere in the Community?
No

Has the same GMO been notified elsewhere by the same notifier?
No

GMO characterization

GMO is a:
DNA Virus

Identity of the GMO:
Genus: Mastadenovirus
Species: human adenovirus.
The GMO DNX-2440 is an oncolytic adenovirus encoding human OX40 ligand, which is a replication competent virus selective of tumoral cells. Its genome contains 3 genetic modifications with respect to the wild type virus (Ad5).


Information relating to the recipient or parental organisms from wich the GMO is derived
Common NameGenusSpeciesSubspeciesStrainPathovar
human adenovirus serotype 5Mastadenovirushuman adenovirussubgenus Chuman serotype 5-

European Commission administrative information

Consent given by the Member State Competent Authority:
Not known